مفخرة للسودان :دكتور سوداني وزملائه بامريكا يقومون باكتشاف طبي جديد يساعد على حماية القلب

Quote: Aspirin And Atherosclerosis Main Category: Pain / Anesthetics Also Included In: Cardiovascular / Cardiology; Biology / Biochemistry Article Date: 23 Sep 2008 - 4:00 PDT email to a friend printer friendly view / write opinions rate article Ads by Google -------------------------------------------------------------------------------- Neuro-interventional Neuro-Endovascular-Surgery Intervetional-Neuroradiology svinr.org Women's Healthcare - UAE Medical Consumer Exhibition healthy lifestyle, family planning www.womenshealthdubai.com/ Current Article Ratings: Patient / Public: 4.6 (5 votes) Health Professional: 4.5 (4 votes) Article Opinions: 0 posts Aspirin has become one of the most widely used medications in the world, owing to its ability to reduce pain, fevers, inflammation, and blood clotting. In animal studies, aspirin has also been shown to prevent atherosclerosis, though none of its known mechanisms of action would seem to account for this. In a new study, though, researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup. Using cell culture and mouse models, Sampath Parthasarathy and colleagues observed that aspirin - specifically its active byproduct salicylate - can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 levels by 7- and 12- fold, respectively. Both of these proteins are beneficial components of the HDL complex, the "good cholesterol" that helps prevent atherosclerosis; ApoA1 removes bad cholesterol from the bloodstream while PON1 is an antioxidant that breaks down toxic lipid peroxides. The researchers also noted that the heightened expression of PON1 was accompanied by an increase in a receptor called AHR (aryl hydrocarbon receptor); this was intriguing as a chemical known to attach to AHR is resveratrol, the "heart healthy" component of red wine. ---------------------------- Article adapted by Medical News Today from original press release. ---------------------------- This study is online in the October issue of Journal of Lipid Research. From the article: "Induction of paraoxonase 1 and apolipoprotein A1 gene expression by aspirin" by Priscilla Jaichander, Krithika Selvarajan, Mahdi Garelnabi and Sampath Parthasarathy Article link: http://www.jlr.org/cgi/content/full/49/10/2188 Corresponding Author: Sampath Parthasarathy, Division of Cardiothoracic Surgery, The Ohio State University Medical Center, Columbus, OH. Source: Nick Zagorski American Society for Biochemistry and Molecular Biology http://www.medicalnewstoday.com/articles/122544.php[/QUOTE]