مفخرة للسودان :دكتور سوداني وزملائه بامريكا يقومون باكتشاف طبي جديد يساعد على حماية القلب

Quote: Aspirin And Atherosclerosis: Mechanism Uncovered ScienceDaily (Sep. 25, 2008) — Aspirin has become one of the most widely used medications in the world, owing to its ability to reduce pain, fevers, inflammation, and blood clotting. In animal studies, aspirin has also been shown to prevent atherosclerosis, though none of its known mechanisms of action would seem to account for this. See also: Health & Medicine * Stroke Prevention * Cholesterol * Heart Disease * Pharmacology * Vegetarian * Human Biology Reference * High density lipoprotein * Low density lipoprotein * Cholesterol * Saturated fat In a new study, though, researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup. Using cell culture and mouse models, Sampath Parthasarathy and colleagues observed that aspirin –specifically its active byproduct salicylate– can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 levels by 7- and 12- fold, respectively. Both of these proteins are beneficial components of the HDL complex, the "good cholesterol" that helps prevent atherosclerosis; ApoA1 removes bad cholesterol from the bloodstream while PON1 is an antioxidant that breaks down toxic lipid peroxides. The researchers also noted that the heightened expression of PON1 was accompanied by an increase in a receptor called AHR (aryl hydrocarbon receptor); this was intriguing as a chemical known to attach to AHR is resveratrol, the "heart healthy" component of red wine. ___________________________ Journal reference: 1. Priscilla Jaichander, Krithika Selvarajan, Mahdi Garelnabi and Sampath Parthasarathy. Induction of paraoxonase 1 and apolipoprotein A1 gene expression by aspirin. Journal of Lipid Research, October, 2008 [link] Adapted from materials provided by American Society for Biochemistry and Molecular Biology, via EurekAlert!, a service of AAAS. Need to cite this story in your essay, paper, or report? Use one of the following formats: APA MLA American Society for Biochemistry and Molecular Biology (2008, September 25). Aspirin And Atherosclerosis: Mechanism Uncovered. ScienceDaily. Retrieved October 12, 2008, from http://www.sciencedaily.com­