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 ورقة علمية لد.حسن : 6 كبابي شاي يوميا تحميك من السرطان
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Drinking lots of tea — preferably green tea, but black tea often seems to work as well — may prevent or even cure many diseases, from obesity to cancer.
This was the message from an all-day series of talks at this week's meeting of the American Chemical Society in New York City. Researchers from Japan and several US institutions reported on their work with both animals and humans, in some cases positing specific molecular pathways for tea's protective effects.
Perhaps the most striking results came from Hasan Mukhtar of the University of Wisconsin Medical Center, who is working with a special mouse model that mimics the progression of human prostate cancer. TRAMP (TRansgenic Adenocarcinoma of the Mouse Prostate) mice, first developed in 1997, have pathologies in their prostates by 10 weeks, and by 28 weeks, 100% of these mice — unless treated — have metastatic cancer.
Mukhtar used two groups of mice, one given water, the other green tea polyphenol (GTP) isolate as their only source of liquid. Mukhtar found that GTP significantly slowed the development of cancer, and its metastasis. The mode of action, he believes, is that the tea compounds inhibit vascular endothelial growth factor and the production of matrix metalloproteases.
Noting that average survival time increased from 42 weeks to 68 weeks, he said that for human prostate cancer, common only in men over 50, delays in onset and progression would effectively mean prevention.
Zigang Dong of the Hormel Institute in Minnesota is studying how tea polyphenols inhibit cancer development as well, with an eye toward a topical cream for skin cancer. While sunblocks absorb UVA, tea components such as EGCG (epigallocatechin gallate) and the theaflavins target the cell-signalling pathways that control both cell proliferation and apoptosis.
Rather than cancer, Jack Bukowski of Brigham and Women's Hospital in Boston is interested in priming the immune system to ward off bacteria, viruses and parasites. He tested two groups of volunteers who ordinarily drank neither tea nor coffee. One group drank 5–6 cups of black tea per day for 4 weeks, the other the same amount of coffee. He found a three-fold increase in the number of gamma delta T lymphocytes in the blood of the tea drinkers — and these cells secreted 5 times as much interferon when challenged with ethylamine.
References:
Hasan Mukhtar & Vaqar Mustafa Adhami. Molecular targets for prevention of prostate cancer by green tea. Paper No. AGFD 61 presented at the 226th National Meetings of the American Chemical Society, New York City, 7–11 September 2003.
Zigang Dong. Modulation of signal transduction and carcinogenesis by food factors. Paper No. AGFD 12 presented at the 226th National Meetings of the American Chemical Society, New York City, 7–11 September 2003.
Jack F. Bukowski & Arati B. Kamath. Tea drinking stimulates immunity. Paper No. AGFD 65 presented at the 226th National Meetings of the American Chemical Society, New York City, 7–11 September 2003.
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HAMZA SULIMAN
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