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 بروفيسير .. مـعـز عـمـر بـخـيـت .. سـيـرة ذاتـيـةعلمـــــية ...
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CURRICULUM VITAE
Qualifications portfolio
Professor Moiz Bakhiet
MD, Ph.D.,
Professor of Molecular Medicine and Neuroimmunology
College of Medicine and Medical Sciences
Arabian Gulf University
Consultant Neurologist
Bahrain Defense Force (BDF) Hospital
Director of HH Aljawhara Center for Molecular Medicine, Genetics and Inherited Diseases
PERSONAL
v Name
v Nationality
v Languages
v Marital status
Moiz Bakhiet
Sudanese - Swedish (Double Nationality)
English, Swedish and Arabic
Married with 4 children
v Work address
v Telephone
v Fax
v E-mail
Department of Molecular Medicine, Arabian Gulf University P.O. Box 26671 Manama, Bahrain
+973 9664120 (mobile) - +973 239664 (Office)
+ 973 271090
[email protected]
v Home address
v Home telephone
v Home Fax
Villa 61, Road, 3603, Area 736 (A’ali)
+973 17642347
+973 17643659
v Current position Professor (AGU)
Consultant Neurologist, Bahrain defense Force (BDF) Hospital
Director of Aljawhara Center for Molecular Medicine (AGU)
Chairman of Research & Ethics Committee
Coordinator for AGU and Karolinska International Research and Training Committee (KIRT), Karolinska Institute, Stockholm, Sweden
Professional qualifications:
v Bachelor of Medicine and Surgery (M.B.B.S.), February 1985
v Ph.D. in Medical Sciences, April 1993
v Clinical Specialty in Neurology, July 1993
v Associate Professor, May 1996
v Competence (full Professor) 2001
v Full Professor June 2002
v Professor Clinical Neuroscience 2003
Faculty of Medicine, University of Khartoum
Karolinska Institute, Stockholm, Sweden
Swedish Board of Health and Welfare
Karolinska Institute, Stockholm, Sweden
Karolinska Institute, Stockholm, Sweden
AGU
Karolinska Institute, Stockholm, Sweden
Clinical portfolio
Current Clinical Position: Senior Consultant Neurologist, BDF Hospital, Manama, Bahrain
1. Clinical competence and formal clinical training
DETAILS FOR SPECIALIST COMPETENCE IN NEUROLOGY
According to the regulations of the Swedish Board of Health & Welfare (SoSFS 1985:1), the requirements for obtaining the degree of specialist competence in Neurology are defined as to be the following:
1. Main Clinical Training: 3 years serving within a recognized department of Neurology
2. Subsidiary Clinical Training.
a. 6 months serving within a recognized department of Internal Medicine
b. 6 months serving within a recognized department of Psychiatry
3. Systematic Theoretical Education: a total of 6 NLV-courses (Courses of the Committee of the Postgraduate Medical Education) are to be chosen from within the subjects of the required specialty attended and be recognized
I have for 5½ year (from 1 September 1989) followed the described training programme. Thereby, I have fulfilled the necessary requirements to obtain the degree of Specialist in Neurology.
Clinical Neurology 3 years
General Medicine
2½ years + (½ year from the Clinical Neurology Period)*, as follows:
Internal Medicine (+Gastroenterology)
6 months
Psychiatry
6 months
Cardiology
3 months
Endocrinology
3 months
Nephrology
3 months
Pulmonary Medicine
3 months
Rheumatology
3 months
Infectious Diseases
3 months + 1 year at the endemic diseases hospital,
Khartoum, Sudan
*Included here to have in total 3 years training in the General Medicine. Parts of the training were conducted in Sudan.
CLINICAL EXPERIENCE
v Number of years as specialist: 11 years
v Experience of posts in inpatient and outpatient care: 19 years
v Appointment as House Officer:
Feb. 1985-Feb. 1986
House Officer, Khartoum Teaching Hospital
v Appointment as Chief Medical Officer:
v March 1986-August 88
v September 88-July 93
v July 1993 – December 1998
v N.B. The period between Mar 95-Feb 96
v January 1998 – December 1998
v January 1999 – August 2000
Senior Medical officer, Shaab Teaching Hosp.
Chief Medical officer following the Clinical Specialty program at the Department of Neurology, Huddinge University Hospital, Stockholm (for details see enclosed certificates)
Physician Neurologist and senior scientist, Department of Neurology, Huddinge University Hospital
Department of Medicine, Molecular Medicine Unit, Karolinska Hospital
Department of Immunology, Microbiology,
Pathology and Infectious Diseases
Department of Medicine, Huddinge University Hospital
v Experience of on-call services: 18 years of standby duty
v Special clinical competence/profile area: General Neurology and Neuroimmunology
v Activities and experience
1. Daily conferences between 8:00 – 8:30 a.m. to present and discuss complicated neurological cases admitted to the department during the last 24h
2. Rounds and all responsibilities related to in-patient care in the ward of clinical neurology
3. Consultations and patient care at the outpatient facilities of the Department
4. 24h of duty to take care of neurological emergency cases around the clock
5. Participation at the unit of neuromuscular diseases including evaluation of patients for neuromuscular diseases, biopsies of muscle, skin and peripheral nerve, morphometry of muscle fibers, immunohistochemistry and histology
6. Doppler ultrasound evaluation of cerebrovascular diseases at the laboratory for ultrasound of the Department
7. Evaluation of complicated pain patients at the pain clinic of the department
8. Evaluation of oligoclonal bands in gel electrophoresis and isoelectrical focusing at the routine lab of the Department
v Examination
Passed an oral extensive examination held by Professor Hans Link, Senior Physician and Chairman of the Department of neurology on July 2, 1993. This examination included all parts, which are necessary for Swedish Neurology Residents when they obtain their specialization.
1. Clinical Administrative Competence
v Acting Head Department of Neurology, Karolinska Institute, Huddinge University Hospital at different occasions from 1996-1998.
v Acting Head Department of Infectious Diseases, Karolinska Institute - Huddinge University Hospital: June – August 1999.
v Medical Director of Al-Shaab Teaching Hospital: August 1987 - July 1988.
v President of the High Committee of Development of Al-Shaab Teaching Hospital – Khartoum: 1987-1988.
v TV introduced for public Medical Information, Scientific and Cultural programs from 1985-1988.
v Collaborate in several national and international multidisciplinary projects
v Has a great ability to manage and collaborate with colleagues and other health and medical personnel
v Secretary, Medical Student Association: 1981-1982
2. Clinical developmental work, research and contributions to clinical training
v Chairman of Clinical Research Committee at BDF and Chairman of Research and Ethics Committee AGU
v For publication of clinical cases and reports see enclosed complete publication list
v Participated in pharmaceutical evaluation for several new drugs (see publication list)
v Participated in testing of new treatment strategies e.g. b-interferon as a treatment for Multiple Sclerosis
v Supervised trainee specialist doctors and other health care personnel (see below).
v Participated in Clinical courses (e.g. NLV courses for specialist training in Clinical Neurology)
4. Current Clinical Position and clinical activities:
Consultant Neurologist, Bahrain Defense Force (BDF) Hospital since February 2002.
Current clinical activities are as above in addition to running my Consultation Referred Clinic at weekly basis at BDF for 4 hours (15 patients per clinic), On Call duties, referrals, clinical meetings and presentations and clinical journal club forums.
Scientific portfolio
1. Scientific production
Original papers:
(Total impact factors 290)
1990
1. Bakhiet M, Olsson T, Van der Meide P and Kristensson K. Depletion of CD8+ T cells suppresses growth of T. brucei brucei and IFN- production in infected rats. Clin Exp Immunol; 81: 195-199. 1990.
1991
1. Olsson T, Bakhiet M, Edlund C, Höjeberg B, Van der Meide P, and Kristensson K. Bidirectional activating signals between Trypanosoma brucei and CD8+ T cells: a trypanosome-released factor triggers interferon gamma production that stimulate parasite growth. Eur J Immunol; 21: 2447-2454. 1991.
2. Nitin G, Bakhiet M, Kristensson K, Norrby E and Olsson T. Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain. J Neuroimmunol 31: 19-26. 1991.
1992
3. Eneroth P, Bakhiet M Olsson T, Kristensson, K. Bidirectional signals between Trypanosoma brucei brucei and dorsal root ganglia neurons. J Neurocytol 21:846-852. 1992.
4. Olsson T, Bakhiet M and Kristensson K. Interactions between Trypanosoma brucei and CD8+ T cells. Parasitology Today 8: 237- 239. 1992.
1993
5. Olsson T, Bakhiet M, Höjeberg B, Ljungdahl Å, Edlund C, Andersson G, Ekre H-P, Fung Leung W-P, Mak T, Wigzell H, Fiszer U, Kristensson K. CD8 is critically involved in lymphocyte activation by a Trypanosoma brucei brucei released molecule. Cell. 72: 715-727. 1993.
6. Bakhiet M, Mix E, Kristensson K, Wigzell H and Olsson T. T cell activation by a Trypanosoma brucei brucei derived lymphocyte triggering factor is dependent on tyrosine protein kinases but not on protein kinase C and A. Eur J Immunol. 23: 1535-1539. 1993.
7. Rottenberg M, Bakhiet M, Olsson T, Mak T, Wigzell H and Örn A. Differential susceptibility of CD4 and CD8 "knock out" mice to infections with Trypanosoma brucei or Trypanosoma cruzi. Infect. Immun. 61: 5129-5133. 1993.
8. Bakhiet M, Olsson T, Edlund C, Höjeberg B, Holmberg K, Lorentzen J and Kristensson K. A Trypanosoma brucei brucei derived factor that triggers CD8+ lymphocytes to interferon gamma secretion: Purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor. Scand. J. Immunol. 37: 165-178. 1993.
1994
9. Olsson T, Kelic S, Edlund C, Bakhiet M, Höjeberg B, van de Meide P, Ljungdahl Å and Kristensson K. Neuronal interferon gamma-like immunoreactive molecule, bioactivities and Purification. Eur. J. Immunol. 24: 308-314. 1994.
1995
10. Zhang G-X, Ma C-G, Bakhiet M, Olsson T and Link H. Depletion of CD8+ T cells has protective effect on experimental autoimmune Myasthenia Gravis in Lewis rats. Eur. J. Immunol. 25: 1191-1198. 1995.
11. Bonfanti C, Caruso A, Bakhiet M, Olsson T, Turano A and Kristensson K. Increased levels of antibodies to IFN- in human and experimental African trypanosomiasis. Scand. .J Immunol. 41: 49-52. 1995.
12. Zhang G-X, Ma C-G, Bakhiet M, Olsson T and Link H. Suppression of experimental autoimmune Myasthenia Gravis after CD8 depletion is associated with decreased IFN-g and IL-4. Scand. J. Immunol. 42: 457-465. 1995.
1996
13. Zhang G-X, Xia B-G, Bakhiet M., Wigzell H. and Link H. Both CD4+ and CD8+ are essential to induce experimental autoimmune Myasthenia Gravis. J. Exp. Med. 184: 349-356. 1996.
14. Bakhiet M., Jansson L., Büscher P., Holmdahl R., Kristensson K. and Olsson T. Control of parasitemia and survival during Trypanosoma brucei brucei infection is related to strain dependent ability to produce interleukin-4. J. Immunol. 157: 3518-3526. 1996.
15. Bakhiet M, Olsson T., Mhlanga J., Büscher P, Lycke N., Van der Meide P and Kristensson K. Human and rodent IFN-g as a growth factor for Trypanosoma brucei brucei. Eur. J. Immunol. 26: 1359-1364. 1996.
16. Bakhiet M, Olsson T, Ljungdahl Å, Höjeberg B, Van der Meide P, Kristensson K. Induction of Interferon-, Transforming growth factor-b and interleukin-4 in mouse strains with different susceptibility to Trypanosoma brucei brucei. J. Interf. Cytok. Res. 16: 427-433. 1996.
17. Andersson M, Löv P. and Bakhiet M. Lovastatin inhibits interferon-g-induced Trypanosoma brucei brucei proliferation: evidence for mevalonate pathway involvement. J. Interf. Cytok. Res. 16: 435-439. 1996.
18. Bakhiet M, Büscher P, Kristensson K, Wigzell H and Olsson T. Different Trypanozoon species possess CD8 dependent lymphocyte triggering factor-like activity. Immunol. Letters. 50: 71-80. 1996.
1997
19. Vaidya T. Bakhiet M, Olsson T., Kristensson K. and Donelson J. The gene for a T-lymphocyte triggering factor from African trypanosomes. J Exp Med 186: 433-438. 1997.
20. Akuffo H, Maasho K, Blomstedt M, Höjeberg B, Britton S and Bakhiet M. Promastigotes of Leishmania aethiopica derived from diffuse cutaneous leishmaniasis patients preferentially induce mRNA for IL-10 while those from local cutaneous leishmaniasis patients induce interferon gamma. J. Infect. Dis. 175: 737-741. 1997.
21. Mustafa E., Bakhiet M., Jaster R., Bittorf T., Mix E. and Olsson T. Tyrosine kinases are required for interferon- stimulated proliferation of Trypanosoma brucei brucei. J. Infect. Dis. 175: 669-673. 1997.
22. Bakhiet M, Diab A, Mustafa M, Zhu J, Lindqvist L and Link H. Potential role of autoantibodies in the regulation of cytokine responses in bacterial infections. Infect. Immun. 65: 3300-3303. 1997.
23. Raqib R, Gustafsson A, Ljungdahl Å and Bakhiet M. Persistent activation of cytokine genes in peripheral blood mononuclear cells during acute and convalescent stages of shigellosis. Infect Immun. 65: 5338-5341. 1997.
24. Diab A, Zhu J, Lindqvist L, Wretlind B, Bakhiet M. and Link H. Haemophilus influenzae and Streptococcus pneumoniae induce different pattern of intracerebral cytokines during the course of experimental bacterial meningitis. Clin. Exp. Immunol. 109: 233-241. 1997.
25. Khalil A., Bakhiet M., Brauner A and Taullus K. Cytokine gene expression in kidneys of mice experimentally infected with Escherichia coli. J. Urol. 158: 1567-1580. 1997.
26. Diab A, Zhu J, Lindqvist L, Wretlind B, Link H and Bakhiet M. Cytokine mRNA profiles during the course of experimental Haemophilus influenzae bacterial meningitis. Clin Immunol. Immunopathol. 85: 236-245. 1997.
27. Mustafa A., Nyberg F., Mustafa M., Bakhiet M., Mustafa E. and Adam A. Growth hormone stimulates production of IFN-g in human mononuclear cells. Horm. Res. 48: 11-15. 1997.
1998
28. Abdel-Halim S, Guenifi A, Bing H, Mustafa M, Höjeberg B, Hillert J, Bakhiet M, and Evendic S. Mutations of adenylate cyclase gene, enhanced expression of adenylate cyclase mRNA and generation of cAMP in the spontaneously diabetic GK rat islets. Diabetes. 47: 498-504. 1998.
29. Elkarim R., Mustafa M., Link H. and Bakhiet M. Cytokine Autoantibodies in multiple sclerosis, Aseptic meningitis and stroke. Eur. J. Clinic. Invest. 28: 295-299. 1998.
30. Mousa A, Mustafa M Wallberg L, Seiger Å and Bakhiet M. Interactions between human embryonic forebrain cells, interferon-g and interleukin-4. Int J Mol Med. 1: 172-176. 1998.
31. Eltayeb R, Mustafa M, Kristensson K, Olsson T, Lycke N, van der Meide P-H. and Bakhiet M. Cytokines and anti-cytokine autoantibodies during experimental African trypanosomiasis in mice with disrupted IFN-g and IFN-g receptor genes. Int J Mol Med. 1: 177-183. 1998.
32. Bakhiet M, Mustafa M, Zhu J, Lindqvist L, Link H and Diab A. Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid during experimental bacterial meningitis in rats. Clin. Exp. Immunol. 114: 398-402. 1998.
33. Elkarim R., Mustafa M., Link H. and Bakhiet M. Recovery from Guillain-Barrié syndrome is associated with increased levels of neutralizing autoantibodies to IFN-g. Clin. Immunol. Immunopathol. 88: 241-248. 1998.
34. Li H, Shi FD, He B, Bakhiet M, Wahren B, Berglöf A, Sandsted K and Link H. Experimental autoimmune myasthenia gravis induction in B cell deficient mice. Int Immunol. 10: 1359-1365. 1998.
35. Zhu J, Deng GM, Diab A, Zwingenber K, Zhou JN, Bakhiet M, Link H. Thalidomide exacerbates experimental autoimmune neuritis in Lewis rats. Scan J Immunol. 48: 397-402. 1998
36. Zhu J, Zou LP, Bakhiet M, Mix E. Resistance and susceptibility to experimental autoimmune neuritis in Sprague-Dawley and Lewis rats correlate with different levels of autoreactive T and B cells responses to myelin antigens. J Neurosci Rec. 54: 373-381. 1998.
37. Mousa A, Mustafa A, Seiger Å, Kjaeldgaard A and Bakhiet M. Tyrosine kinases are potentially involved in growth stimulation of human first trimester forebrain cells by interferon-. Neuroreport. 9: 4097-4101. 1998.
38. Mousa A, Seiger Å, Kjaeldgaard A and Bakhiet M. Human first trimester forebrain cells express genes for inflammatory and anti-inflammatory cytokines. Cytokine. 11: 55-60. 1998.
1999
39. Bakhiet M, Özenci V., Withagen C, Fredrikson S and Link H. A new cell enzyme-linked immunosorbent assay demonstrates gamma interferon suppression by beta interferon in multiple sclerosis. Clin Diagn Lab Immunol. 6: 415-9. 1999.
40. Bakhiet M, Elkarim R, Diab A, Zhu J, Lindqvist, L Link H and Mustafa M. A novel mechanism for cytokine regulation: Screening, selection and characterisation of anti-cytokine monoclonal and polyclonal autoantibodies. J Interf. Cytok. Res. 19: 439-445. 1999.
41. Diab A, Li H-L, Zhu J, Lindquist L, Wretlind B., Bakhiet M and Link, H. Neutralization of MIP-2 and MIP-1a attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis. Infect. Immun. 67: 2590-601. 1999.
42. Hamadien M, Lycke N and Bakhiet M. Induction of the trypanosome lymphocyte triggering factor and its antibodies in mice with different susceptibilities to African trypanosomiasis. Immunology. 96: 606-611. 1999.
43. Elkarim R., Mustafa M., Lindqvist L., Link H. and Bakhiet M. Levels of gamma interferon and interleukin-4 are inversely related to the levels of their corresponding autoantibodies in patients with lower respiratory tract infection. Infect Immun. 67:3051-4. 1999.
44. Elkarim R., Mustafa M., Ekerfelt C., Ernerudh J., Link H. and Bakhiet M. Induction of neutralizing autoantibodies to interferon-gamma in patients with polyneuropathy. Hum. Antibodies. 9: 55-60. 1999.
45. Zhu J, Bai XF, Björk J, Hedlund G, Bakhiet M, Link H. Linomide suppresses experimental allergic neuritis in Lewis rats by inhibiting myelin antigen-reactive T and B cells responses. Clin. Exp. Immunol. 115: 56-63. 1999.
46. Liu Y, Li Z and Bakhiet M. Upregulation of the chemokines Rantes, MCP-1, MIP-1a and MIP-2 in early infection with Trypanosoma brucei brucei and inhibition by sympathetic denervation of the spleen. Trop. Med. Int. Health. 4: 85-92. 1999
47. Sharafeldin A, Hamadien M, Diab A, Khalil A, Li H-L, Shi F-D, and Bakhiet M. Cytokine profiles in the central nervous system and the spleen during the early course of experimental African Trypanosomiasis in rat. Scand. J. Immunol. 50:256-261. 1999.
48. Xiao B-G., Mousa A., Kivisäkk P, Bakhiet M. and Link H. Induction of b-family chemokines mRNA in human embryonic astrocytes by inflammatory cytokines and measles virus. J. Neurocytol. 27: 575-80. 1999.
49. Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J. Interferon. Cytokine Res. 19: 1047-1052. 1999.
50. Liu Y, Li Z, Nuortio L and Bakhiet M. Interferon-g and interleukin-12 genes are preferentially expressed during early experimental African trypanosomiasis and suppressed by splenic denervation of the spleen. Scand. J. Immunol. Scand. J. Immunol. 50: 485-91. 1999.
51. Wang HB, Li H, He B, Bakhiet M, Levi M, Wahren B, Berglof A, Sandstedt K, Link H, Shi FD. The role of B-cells in experimental myasthenia gravis in mice. Biomed Pharmacother 53:227-33. 1999.
52. Bakhiet M. The role of autoantibodies in the action of cytokines. Frontiers in multiple sclerosis III. EDS: Martin Dunitz Ltd, London. 1999.
2000
53. Eltayeb R, Sharafeldin A, Robert Jaster, Thomas Bittorf, Mix E and Bakhiet M. Trypanosoma brucei brucei induces interferon-g expression in rat dorsal root ganglia cells via a Tyrosine protein kinase-dependent pathway. J. Infect. Dis. 181: 400-404. 2000
54. Sharafeldin A, Eltayeb R, Patchenkov Ml and Bakhiet M. Chemokines are early expressed during the course of experimental African trypanosomiasis. J Neuroimmunol. 103: 165-170. 2000.
55. Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Orthodontic movement induces high numbers of cells expressing IFN-g at mRNA and protein levels. J. Interf. Cytok. Res. 20: 7-12. 2000.
56. Hamadien M, Bakhiet M and Harris R. Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. Parasitology. 120: 281-287. 2000.
57. Nordlind K, Eriksson L, Seiger Å and Bakhiet M. Expression of interleukin-6 in human spinal ganglion cells. Neuroscience Letters. 280: 139-142. 2000.
58. Khalil A, Tullus K, Bakhiet M, Burman LG, Jaremko G and Brauner A. Angiotensin II type 1 receptor antagonist (Losartan) reduces transforming growth factor-b in experimental acute pyelonephritis. J. Urol. 164:186-191. 2000.
59. Mustafa M, Bakhiet M, Wondimu Band Modéer T. Induction of interferon-g in human gingival fibroblasts challenged with phytohemagglutnin. Cytokine. 12: 368-73. 2000.
60. Khalil A., Bakhiet M., Taullus K. and Brauner A. Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6 deficient mice Clin. Exp. Immunol. 122: 200-206. 2000.
61. Falsafi-Amin H, Lundberg L, Bakhiet M and Nordlind K. Early synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects. Int. Arch. Allergy Immunol. 123:170-176. 2000.
62. Mustafa M, Modéer T and Bakhiet M. Triclosan suppresses both interferon-g production and MHC class-II expression by human gingival fibroblasts. J. Clin. Periodontol. 27: 733-737. 2000.
63. Liu Y, Mustafa M, Li H-L, Nuortio L, Mustafa A and Bakhiet M. Modulation of early immune responses and suppression of Trypanosoma brucei brucei infections by surgical denervation of the spleen. Neuroimmunemodulation. 8: 31-38. 2000.
64. Grant K, Abdalla H, Diab A, Lindquist L, Bakhiet M and Andersson J. CNI suppresses experimental bacterial meningitis and increases survival rate by inhibiting TNF-a and IL-1b production Infec. ImmunInfect Immun. 68: 5329-34. 2000.
2001
65. Bakhiet M, Tjernlund A, Mousa A, Gad A, Strömblad S, Seiger Å and Andersson J. Rantes promotes growth and survival of human first trimester forebrain astrocytes. Nature CB. 2: 150-157. 2001.
66. Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Orthodontic movement induces de novo synthesis of proinflammatory cytokines. Am. J. Orthod. Dentofacial Orthop. 119: 307-312. 2001
67. Mustafa M, Wondimu B, Bakhiet M, Modéer T. Production of Rantes/CCL5 in human gingival fibroblasts challenged with tumor necrosis factor alpha. Eur. J. Oral Sci. 109: 44-9. 2001.
68. Nylen S, Mortberg U, Kovalenko D, Satti I, Engstrom K, Bakhiet M, Akuffo H. Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors. Clin. Exp. Immunol.124: 43-53. 2001.
69. Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry-Central Nervous System. 1: 201-208.2001.
2002
70. Bakhiet M, Hamadien M, Tjernlund A, Mousa A and Seiger Å. African trypanosomes activate human embryonic forebrain cells to proliferation and IFN-g production. NeuroReport. 13: 53-56. 2002.
71. Bakhiet M, Mousa A, Seiger A, Andersson J. Constitutive and inflammatory induction of alpha and beta chemokines in human first trimester forebrain astrocytes and neurons. Mol Immunol 38: 921-929. 2002
2003
72. Hertting O, Khalil A, Jaremko G, Chromek M, Li YH, Bakhiet M, Bartfai T, Tullus K, Brauner A Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice. Clin Exp Immunol 131:2 225-33. 2003
73. Chen Z, Yu S, Bakhiet M, Winblad B, Zhu J. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. J Neurochem. 86: 61-68. 2003
74. Al-Sallom FS, Al-Mahmeed A, Ismaeel A, Botta GA, Bakhiet M. Campylobacter-stimulated INT407 cells produce dissociated cytokine profiles. J Infect. 2003; 47: 217-24.
2004
75. Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. CD40-CD40L expression during orthodontic tooth movement in rats. Angle Orthod. 2004; 74:100-105.
76. Bakhiet M, Al-Salloom FS, Qareiballa A, Bindayna K, Farid I, Botta GA,. Induction of alpha and beta chemokines by intestinal epithelial cells stimulated with Campylobacter jejuni. J Infect. 2004; 48: 236-44.
77. Liu Y, Li Z, Svaren-Quiding C, Cui J, Ozenci V, Bakhiet M. Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats. Neuroimmunomodulation. 2004; 11: 113-8.
78. Ahmed Sharafeldin, Eilhard Mix, Robert Harris Tomas Bittroff and Moiz Bakhiet. Prolonged induction of three transcription factors in Trypanosoma brucei brucei by interferon-g via a tyrosin kinase-dependent signal pathway. Acta Protozoa .In Press
79. Moiz Bakhiet and Ahmed Sharafeldin. Immune responses in the brain and signaling pathways in experimental African trypanosomiasis. Recent Research Developments in Infection & Immunity. In Press.
80. Moiz Bakhiet. Regulation of cytokine responses in infections and autoimmune diseases by anti-cytokine autoantibodies. Recent Research Developments in Immunology. In Press.
Submitted
Twenty one (21) papers are submitted recently
v Summary of overview articles and chapters in text-books
1. Olsson T, Bakhiet M and Kristensson K. Interactions between Trypanosoma brucei and CD8+ T cells. Parasitology Today 8: 237- 239. 1992.
2. Bakhiet M. The role of autoantibodies in the action of cytokines. Frontiers in multiple sclerosis III. EDS: Martin Dunitz Ltd, London, in press. 1999.
3. Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry-Central Nervous System. 1: 201-208.2001.
Research resulted in International Patents:
Lymphocyte stimulating factor-P-CA2998004, AWAPATENT, International patent 2000.
v Summary of other scientific work
Ph.D. Examination Committees
1. Ph.D. thesis of Dr. Bao-Gua Xiao, 8/11/1996.
2. Ph.D. thesis half-time exam of Dr. Bai Xuefeng 3/3/1997
3. Ph.D. thesis of Dr. Tiamin Liu, 28/11/1997.
4. Ph.D. thesis of Dr. Anna-Fogdell, 19/12/1997
5. Ph.D. thesis of Dr. He Bing, June 1998
6. Ph.D. thesis of Dr. Fo-Dong, May 1998
7. Ph.D. thesis of Dr. Chun Xu, May 1999
8. Ph.D. thesis of Mats Remberger, October 1999
9. Ph.D. thesis of Li-Ping Zou, December 1999
Potential reviewer for the following journals:
1. Infection and Immunity
2. Parasitology Today
3. Parasite Immunology
4. Scandinavian Journal of Immunology
5. Immunology Letters
6. Brain Research Bulletin
7. Neuroimmunemodulation
8. Nature Cell Biology
9. Journal of Odontology
10. The Angle Orthodontist
11. Bahrain Medical Bulletin
Potential reviewer for several foundations in relation to grant applications
Expert on the following techniques
Beside clinical experience in Medical Neurology procedures, I have the experience on the following techniques:
IMMUNOLOGY:
1. Immunospot assay (ELISPOT)
2. Proliferation assay
3. Monoclonal making (immunization, hybridoma making, cell cloning and cultivation, purification)
4. Enzyme Linked Immunosorbant assay
5. Western blot, SDS page blotting
6. Immunohistochemistry
7. Cells Enrichment assays
8. Affinity purification techniques
9. FACS techniques and analysis
MOLECULAR BIOLOGY:
1. Restriction of DNA, isolation of total and mRNA
2. Agarose gel electrophoresis
3. PCR technique
4. Ligation of PCR products, transformation and plating of transformed bacteria.
5. Southern blotting
6. Preparation of plasmid DNA and restriction analysis
7. Amino acid gel sequencing
8. DNA sequencing
9. cDNA gene library construction and screening
10. In situ hybridization
EXPERIMENTAL MODELS IN MICROBIOLOGY AND IMMUNIOLGY:
1. Animal model for experimental trypanosomiasis
2. Animal model for bacterial infections (meningitis, UTI)
3. Experimental models for viral infections (VSV, Measles, Mumps)
4. Animal model for Autoimmune diseases (myasthenia gravis, EAE, EAN)
GENERAL:
1. Microscope, image analysis and photo techniques
2. Medical statistics
3. Computer applications in IBM (DOS and Windows applications, in addition to experience in IBM hardware), and in Macintosh software.
Summary of abstracts
v Bidirectional activating signals between T. b. brucei and CD T cells. International meeting on lymphoid cells and molecules in infection and immunity, Elsinore, Denmark.14/5/1991.
v CD8 is critically involved during Experimental African trypanosomiasis. First "Acrival Meeting" on chemotherapy of trypanosomiasis, Marseilles, France.15-16 /6/ 1992.
v IFN-g as a growth promoting molecule for T. b. brucei. Commission of the European Community, COST Co-operation, Second Acrival COST meeting on Treatment African Trypanosomiasis, University of Budapest, Hungary. 3-4 /6/ 1993.
v Interactions between T. b. brucei and CD8+ lymphocytes. 27th Trypanosomiasis Seminar. London School of Hygiene and Tropical Medicine, UK.15-16 /6/ 1993.
v Bidirectional signals between T. b. brucei and dorsal root ganglia. 4th International Congress of neuroimmunology, RAI, Amsterdam, Holland. 22/10/1994.
v African Trypanosomes and Immunoregulating Molecules. Medical Faculty of the University of Gothenburg. XXVIth Annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.25/5/1995.
v Interactions between T. b. brucei and immunoregulating molecules. 9th International Congress of Immunology. San Francisco, USA.23-29 /7/ 1995.
v Interactions between T. b. brucei and immunoregulating molecules. BSP seminar on trypanosomiasis and leishmaniasis, Glasgow, UK.2-6 /9/ 1995.
v Immunobiolog of T. b. brucei. BSP symposium on immunobiology of trypanosomiasis and leishmaniasis, Glasgow, UK.3/9/1995.
v Pathogenesis of Shigellosis. International cytokine symposium, UK, September 1995.
v Interactions of Trypanosoma brucei brucei and the immune system. Trypanosome workshop, BMC, Uppsala .19/1/1996.
v Role of IL-4 in control of parasitaemia and survival in resistant and susceptible mouse strains to Trypanosoma infection, Cytokine and cytokine receptor workshop, Turku, Finland. 25/5/1996
v Interferon-b-1b treatment of multiple sclerosis patients suppresses both myelin basic protein-specific and pha-induced interferon-g production: an effect demonstrated by a new cell released capturing (crc)-elisa. Swedish Medical Association Annual meeting, Stockholm, Sweden. 29/11/1996.
v Control of Trypanosoma brucei infection depends on non-MHC gene ability to produce IL-4. The 6th Scientific Conference, The Sudanese Association of Pathologists, Khartoum, Sudan. Sharga Hall, Khartoum, Sudan 5 January 1997.
v Tyrosine kinases are required for interferon- stimulated proliferation of Trypanosoma brucei brucei. The 3rd Conference of the Federation of African Societies for Immunology, Cape Town, South Africa. 11 March 1997.
v Interaction between T. b brucei and immunoregulating molecules The 30th Conference of the Arab Doctors, Sana’a Yemen. 15-17 July 1997
v Recovery from Guillain Barrié syndrome is associated with increased levels of neutralizing autoantibodies to IFN-g. The 5th International Congress of human antibodies and hybridomas, 15-17 April 1998, Washington DC, USA. 15-17 April 1998
v A nervous system induced factor inducing cytokines in immune cells. The International Summer School, Gothenburg, Sweden. 23-27 August 1998
v A nervous system induced factor inducing cytokines in immune cells. The 5th International Congress of Neuroimmunology, Montreal, Canada. 25-2 July 1998
v A major cession talk, the role of autoantibodies to cytokines, the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden .The 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Stockholm, Sweden. 9-12 September 1998
v Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The 31
Pan Arab Congress, Khartoum, Sudan, 7-8 December 1998
v Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The ITM colloquium Congress, Antwerp, Belgium 14-17 December 1998
v Immunopathogenesis of experimental bacterial meningitis: Effects of immune modulation. The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000.
v A nervous system induced factor inducing cytokines in immune cells. The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000
v Tyrosine protein kinases are potentially involved during Trypanosoma brucei brucei derived lymphocyte triggering factor (TLTF) activation of dorsal root ganglia neurons. The 9th International Conference of Infectious Diseases, 9 -13 April 2000, Buenos Aires, Argentina
v Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. The 4th annual Woods Hole Immunoparasitology Meeting, April 16 - 19, 2000 - MBL Woods Hole, MA, USA.
v Rantes promotes growth of human embryonic astrocytes. Immunology 2000. The American Association of Immunologist and Clinical Immunology Society joint annual meeting. 12 - 16 May, 2000. Seattle, WA, USA.
v Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. The 10th European Congress of Clinical Microbiology and Infectious Diseases. May 28 - 31, 2000 - Stockholm, Sweden.
v The mechanism of cytokine action. Does dose matter? August - 31, 2000. The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis- Stockholm, Sweden.
v Rantes promotes growth of human embryonic astrocytes. April 21- 26, 2001. The 11th International Conference on phosphorylated protein. Melbourne, Australia.
v Chemokine and chemokine receptors, The 11th International Congress of Immunology. 18-26 August 2001. Stockholm, Sweden.
v Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for IFN-b in the treatment of multiple sclerosis. 20-22/4/2002 Second Al Ain International Immunology Meeting.
v Induction of a and b chemokines by intestinal epithelial cells stimulated with Campylobacter jejuni. International Conference of Infectious Diseases - Cancun, Mexico - 3-7 March 2004.
Other scientific merits:
1. Active participation in international scientific congresses as an invited speaker:
15-16 June, 1992 First "Acrival meeting" on chemotherapy
of trypanosomiasis, Marseilles, France
3-4 June 1993 Commission of the European Community, COST Co-operation, Second Acrival COST meeting on Treatment of African Trypanosomiasis, Budapest Hungary
15-16 September 1993 27th Trypanosomiasis Seminar - London School of Hygiene and Tropical Medicine
22 October 1994 4th International Congress of neuroimmunology, RAI, Amsterdam, Holland
25-28 May 1995 XXVIth Annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.
23-29 July 1995 9th International Congress of Immunology
San Francisco, USA
2-6 September 1995 BSP meeting on trypanosomiasis and leishmaniasis
Glasgow, UK
19 January 1996 Trypanosome Workshop, BMC, Uppsala, Sweden
24-27 May 1996 XXVIIth Annual meeting, Scandinavian Society for
Immunology, Turku, Finland.
28-30 November 1996 Swedish Medical Association Annual meeting, Sweden
4-6 January 1997 The 6th Scientific Conference, The Sudanese
Association of Pathologists, Khartoum, Sudan
9-13 March 1997 The 3rd Conference of the Federation of African Societies for Immunology, Cape Town, South Africa
15-17 July 1997 The 30th Conference of the Arab Doctors, Sana’a Yemen.
14-16 September 1997 The 5th CFN Symposium on effects of toxicants on gene expression and intracellular signalling - Stockholm.
15-17 April 1998 The 5th International Congress of human antibodies and
hybridomas, 15-17 April 1998, Washington DC, USA.
25-2 July 1998 The International Summer School, Gothenburg, Sweden.
23-27 August 1998 The 5th International Congress of Neuroimmunology, Montreal, Canada
9-12 September 1998 The 14th Congress of the European Committee for treatment and research in multiple Sclerosis, Stockholm
7-11 November 1998 The 31 Pan Arab Congress, Khartoum, Sudan
14-17 December 1998 The ITM colloquium Congress, Antwerp, Belgium
27/6-2 July 1999 The 10th International Congress on Mucosal Immunity. Amsterdam. Holland.
28/8 – 2 September 1999 1999 meeting on HIV/AIDS and Cancer Biology - Baltimore, Maryland - USA
17/1 – 19 January 2000 The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000
9 -13 April 2000 The 9th International Conference of Infectious Diseases, , Buenos Aires, Argentina
April 16 - 19, 2000 The 4th annual Woods Hole Immunoparasitology Meeting, - MBL Woods Hole, MA, USA
12 - 16 May 2000 Immunology 2000. The American Association of Immunologist and Clinical Immunology Society joint annual meeting.. Seattle, WA, USA
May 28 - 31, 2000 The 10th European Congress of Clinical Microbiology and Infectious Diseases - Stockholm, Sweden.
August - 31, 2000 The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis, Sweden.
April 21- 26, 2001 The 11th International Conference on phosphorylated protein - Melbourne, Australia
August 26/8/2001 Chemokine and chemokine receptors- 11th International Congress of Immunology - Stockholm - Sweden
April 20-22/2002 Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for IFN-b in the treatment of multiple sclerosis Second Al Ain International Immunology Meeting.
June 16-21, 2002 11th International Congress of Mucosal Immunology, Orlando, USA
October 16-17, 2002 3rd GCC Neurology Conference, Bahrain
February 20-23, 2003 The International Symposium of the Immune System in Health and Disease. Osaka, Japan
October 06-08, 2003 Saudi German Academy second international meeting, Jeddah, Saudi Arabia
December 09-12, 2004 International Symposium on Genetics, Dubai – United Arab Emirates
March 03-07, 2004 International Congress f Infectious Diseases, Cancun, Mexico
2. Fellowships and scholarships
v 1988-1991
v 1991-1992
v 1992-1994
v 1995-1999
v 1999- 2001
Departmental Fellowship, Departments of Neurology and neurobiology, Karolinska Institute, Huddinge University Hospital
Training allowance from Karolinska Institute
WHO, TDR fellowship
Medical Research Council (MRC) Research Position
Karolinska Institute Research Position
2. Scientific collaboration and external research grants
SCIENTIFIC COLLABORATION:
1. Professor Hans Wigzell, MTC, Karolinska Institute, Stockholm, Sweden.
2. Professor Jan Andersson, Division of Infectious Diseases, Huddinge Hospital, Sweden.
3. Professor John Donelson, Howard Hughes Medical Center, University of Iowa USA.
4. Professor CC Wang, Department of Chemistry, University of California, USA.
5. Dr. William Kuzel, Institute for Cellular and Molecular Biology, University of Texas
6. Professor Phillipe Büscher, Institute of Tropical Medicine, Antwerp, Belgium.
7. Professor Peter van der Meide, TNO Center, Rijswijk, The Netherlands.
8. Dr. Eilhard Mix, University of Rostock, Department of Neurology, Germany.
9. Dr. Abdel Rahman Tambal, Director General National Health Laboratories, Khartoum
WORK IN LABORATORIES OUTSIDE SWEDEN:
1. Institute of Tropical Medicine, Antwerp, Belgium, May - June 1994.
2. Department of Biochemistry, Howard Hughes Medical Center, University of Iowa USA. June - July 1995.
3. Neuroimmunology lab, University of Rostock, Germany, November 1993, December 1994.
4. Visited the following labs for sharing experience:
Ö Hopital Robert Debre – Paris – France (February 2003)
Ö Hopital Saint-Louis – Paris - France (February 2003)
Ö Center Hopitalier Universitaire de Rouen – France (February 2003)
Ö King Faisal Specialist Hospital and Research Center - Riyadh, Saudi Arabia (03/2003)
Statement of the current granted research funds
Strategic Research, Junior Promising Researcher
550.000 SEK
MFR
486.000 + 330.000 SEK
WHO, Director Initiative Fund
120.000 SEK
Kapten Artur
100.000 SEK
KI-FOND
46.000 SEK
SLS
70.000 SEK
Magn Begvalls Stiftelse
40.000 SEK
A Eriksson
20.000 SEK
FoUU
600.000 SEK
Harald och Greta Jeanssons Stiftelse
130.000 SEK
AGU, Campylobacter Project
20.000 BD (500.000 SEK)
AGU, Trypanosoma Project
5.000 BD (12500.000 SEK)
3. Supervision of doctoral candidates/postgraduate teaching
Graduated scientists under my supervision:
Ph.D. degree
1. Asim Diab, June 1998
2. Alyaa Mousa, December 1998
3. Rihab Elkarim, 18 October 1999
4. Ragaa Eltayeb 12 October 2000
5. Ahmed Sharafeldin December 2001
6. Maha Hamadien 30 August 2002
7. Najat Alhashimi: 26 August 2004
Licentiate (M Phil) degree
1. Najat Alhashimi: 23 August 1999
2. Maha Hamadien: 25 August 1999
3. Liu Yajuan: 29 October 1999
4. Ahmed Sharafeldin 8 November 1999
5. Hana Abdalla, 10 March 2000.
Master degree
Anneli Tjernlund, June 1998
Pontus Thulin, August 2000
Fajer Al-Saloom, October 2002
Amani Alzaki Feb 2004
Habib Yousif MArch 2004
Ahlam Alamri April 2004
Registered Ph.D. students
New 4 PhD students are registered under the Molecular Medicine PhD Program
Master student, agu:
Ali Albahrani
Khulood Suliman Al-Wesebai
Abdulhadi Ali Al-bannawi
Pedagogical portfolio
1. Formal pedagogical education
COURSES ATTENDED
v At Karolinska Institute
March – April 1989
October, 1989
13-17 May, 1991
30/9 - 25/11, 1992
2 – 6 October 1995
2 /12 1999 – May 2000
A course over 2 months, full-time in clinical neurology
Demyelinating diseases and infections in the nervous system, Department of Neurology Huddinge Hospital, Karolinska Institute
Immune mechanisms in pathogenesis of Nervous system diseases, Department of Neurology Huddinge Hospital
Molecular Analysis of Genetic Diseases, Karolinska Institute, Department of Molecular Genetics
Course for teaching at tertiary level, Karolinska Institute,
Pedagogic Forum, Huddinge University Hospital
v Outside Karolinska Institute
9-12 June, 1991
10/4 - 14/4/1994
15-16 September 1993
17 September 1993
25-28 May 1995
19 January 1996
23-25 May 1997
25/6 - 2/7/1998
7-8 December 1998
The Summer School of the 11th European Immunology meeting in Finland
Basic Molecular Biology Course. Lancaster University, Department of Biological Sciences, England.
27th Trypanosomiasis Seminar. London School of Hygiene and Tropical Medicine
The Symposium of the British Society for Parasitology on the Protozoan Surface Molecules, City University, London, UK.
Satellite symposium on cytokines of the XXVIth annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.
Trypanosome Workshop, Biomedical Center, Uppsala, Sweden
8th International Center for Biotechnology Symposium on Cytoplasmic Protein. Tyrosine Kinases. Novum Research Park, Stockholm
The International Summer School, Gothenburg, Sweden
The 1998 Scientific Symposium on innate signals of the New York Academy of Medicine, New York, USA
5 October 2000
Tutoring skill workshop, AGU, Bahrain
12 December 2000
Workshop on Construction of Integrated True and False Multiple Choice Questions, AGU, Bahrain
12 October 2002
Workshop on Construction of Educational problems
23-25 April 2003
Workshop on Evidence-based Medicine, AGU, Bahrain
Participation in teacher for lecturing at foreign universities and in international meetings
14/5/1991 Bi-directional activating signals between T. b. brucei and CD8+ T cells. International meeting on lymphoid cells and molecules in infection and immunity, Elsinore, Denmark
15-16 /6/ 1992 CD8 is critically involved during Experimental African trypanosomiasis. First "Acrival Meeting" on chemotherapy of trypanosomiasis, Marseilles, France
3-4 /6/ 1993 IFN-g as a growth promoting molecule for T. b. brucei Commission of the European Community, COST Co- operation, Second Acrival COST meeting on Treatment African Trypanosomiasis, University of Budapest
Hungary
15-16 /6/ 1993 Interactions between T. b. brucei and CD8+ lymphocytes 27th Trypanosomiasis Seminar - London School of Hygiene and Tropical Medicine, UK
4/11/1993 A seminar on Parasite Immunology, Organized by Sudan Association of Physicians - Faculty of Medicine, University of Khartoum, Sudan
13/12/1993 Interaction between African Trypanosomes and the Immune system, University of Rostock, GERMANY
22/10/1994 Bidirectional signals between T. b. brucei and dorsal root ganglia. 4th International Congress of neuroimmunology, RAI - Amsterdam, Holland
21/7/1995 Sleeping Sickness: Interactions between T. b. brucei and the immune system - Department of Neurology. University of Iowa, Iowa city, USA
23-29 /7/ 1995 Interactions between T. b. brucei and immunoregulating molecules - 9th International Congress of Immunology - San Francisco, USA
2-6 /9/ 1995 Interactions between T. b. brucei and immunoregulating molecules - BSP seminar on trypanosomiasis and leishmaniasis - Glasgow, UK
3/9/1995 immunobiology of T. b. brucei - BSP symposium on immunobiology of trypanosomiasis and leishmaniasis, Glasgow, UK
10/1/1996 Strategies for Molecular Characterization of Parasite factors - Faculty of Medical Technology - University of Khartoum
15/1/1996 Parasite Signalling Pathways - Unit of Genetics and Molecular Parasitology, National health Laboratory, Institute of Endemic Diseases, University of Khartoum.
16/1/1996 Molecular Cloning a CD8-dependent trypanokine factor - Faculty of Medicine - University of Khartoum
17/1/1996 New strategies on Parasite Research - Faculty of Medical Laboratories, Omdurman Ahlia University
25/5/1996 Role of IL-4 in control of parasitemia and survival in resistant and susceptible mouse strains to Trypanosoma infections, Cytokine and cytokine receptor workshop, Turku, Finland.
17/10/1996 Early signalling pathways involved in the interactions between micro-organisms and the immune system. Department of Neurology - Beijing Hospital, China
5/1/1997 Control of Trypanosoma brucei infection depends on non-MHC gene ability to produce IL-4. Sharja Hall, Khartoum, Sudan
7/1/1997 Over view of the innate immune reactions and early signals - National health Laboratory, Institute of Endemic Diseases, University of Khartoum..
12/1/1997 Adenyl cyclase gene analysis in type II diabetes - Faculty of Medicine, University of Khartoum
11/3/1997 Tyrosine protein kinases are required for IFN-g induced T.b. brucei proliferation. Arthur’s seat Hotel - Cape Town
15/7/1997 Interaction between T.b brucei and immunoregulating molecules – Sanaa – Yemen - Sheraton Hotel
15/4/1998 Recovery from Guillain Barrié syndrome is associated with increased levels of neutralizing autoantibodies to IFN-g. Washington DC, USA.
6/6/1998 Interactions between African trypanosomes and immunoregulating molecules - Arabian Gulf University, Bahrain
2/7/1998 A nervous system induced factor inducing cytokines in immune cells. The International Summer School - Gothenburg, Sweden
11/9/1998 A major cession talk, the role of autoantibodies to cytokines, the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden
7/11/1998 Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The 31 Pan Arab Conference - Khartoum, Sudan.
8/11/1998 Autoantibodies to cytokines, a novel immunoregulatory mechanism, Institute of Endemic Diseases, Khartoum, Sudan
16/11/1998 Cytokines in health and disease - The UAE University - United Arab Emirate
17/12/1998 Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The ITM colloquium, Antwerp, Belgium
27/6/1999 Anti-cytokine autoantibodies as novel mechanism for cytokine regulation and therapy - Saudi German Hospital Jeddah - Saudi Arabia
17/1/2000 Modulation of immune responses in experimental bacterial meningitis - Saudi German Hospital - Jeddah Saudi Arabia
19/1/2000 A novel approach to treat neuroinflammatory and autoimmune disorders. Saudi German Hospital - Jeddah. Saudi Arabia
23/1/2000 Cytokines in health and disease - Department of Physiology - King Saudi University - Riyadh - Saudi Arabia
26/1/2000 Regulation of cytokine responses in infectious diseases - Dubai Medical University - Dubai, United Arab Emirates
18/5/2000 Immune responses within the CNS, Department of Chemistry - University of California, San Francisco - USA
31/8/2000 The mechanism of cytokine action - Does dose matter? The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis- Stockholm, Sweden.
12/3/2002 Constitutive and inflammatory induction of chemokines in embryonic brain - Al Ain Second International Immunology Meeting, UAE 11-14 March 2002
18/6/2002 Induction of proinflammatory cytokines by INT407
epithelial cell line challenged with Campylobacter Jejuni, 11th International Congress of Mucosal Immunology, Orlando, USA
8/10/2003 Factors regulating brain development. State of art Lecture – Saudi German Medical Academy - Jeddah
22/07/2004 Recent Advances in Multiple Sclerosis. Military Hospital Omdurman - Sudan
Seminars presented in Sweden:
v At Karolinska Institute:
19/10/1993 African Trypanosomiasis - Interaction between the parasite and the Immune System - Seminars in experimental Infections and Parasitology - Department of Clinical Immunology, Huddinge Hospital, SWEDEN
22/2/1994 The Immune system and trypanosomiasis - Department of Rheumatology, Research section - Karolinska Hospital. Sweden
23/9/994 Knock-out techniques; updates on cytokine receptors during infection. Department of Clinical Neuroscience, Huddinge Hospital,. SWEDEN.
1/5/1995 IFN-g receptor oriented research in trypanosomiasis. Department of Molecular Medicine - Karolinska Hospital, April 1995. Sweden.
19/1/1996 Early events in immune system defense mechanisms. Huddinge Hospital
2/8/1996 Overview of the immune system - Postgraduate course - Huddinge Hospital, division of neurology
27/8/1996 A novel autoantibody regulatory mechanism for cytokine responses, MTC, Karolinska Institute
17/2/1997 Molecular aspects of T.b. brucei induced pathology. Joint seminar – library - Huddinge University Hospital
6/3/1998 IFN-g as a growth factor for African trypanosomes. IMPI-
MTC Seminar, Division of Infectious Diseases, Huddinge Hospital, Karolinska Institute.
17/6/1998 Immunoregulation to cytokines by autoantibodies, MTC, Karolinska Institute, Stockholm, Sweden
9/2/1999 A potential immunoregulatory role for anti-cytokine antibodies - Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
25/2/1999 The above lecture was presented at the Department of Clinical Pharmacology, Karolinska Hospital, Sweden
17/5/1999 The above lecture was presented at the Department of Clinical Microbiology, Karolinska Hospital, Sweden
10/1/2000 Over view of innate and acquired immunity, course in immune system and trauma for medical students, Department of Anesthesia, Huddinge Hospital, Sweden
10/1/2000 The CNS and the immune system, course in immune system and trauma for medical students, Department of Anesthesia, Huddinge Hospital, Sweden
16/11/2002 Cytokines in Multiple Sclerosis3rd GCC Neurology Conference, Bahrain
v At other universities in Sweden:
25/5/1995 African Trypanosomes and Immunoregulating Molecules Medical Faculty of the University of Gothenburg
28/5/1995 Cytokines and cytokine receptors- Xth Summer School, Gothenburg
19/1/1996 Interactions of Trypanosoma brucei brucei and the immune system - Trypanosome workshop, BMC, Uppsala
9/5/1996 Interactions of Trypanosoma brucei brucei and the immune system - Trypanosome workshop, BMC, Uppsala
25/11/1997 Interaction between T.b. brucei and immunoregulating Department of Molecular and Cell Biology, Umeå
University, Sweden.
11/9/1998 A major cession talk, the role of autoantibodies to cytokines, the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden
8/2/1999 Autoantibodies to cytokines, Clinical and therapeutic relevance Department of Clinical Immunology, University of Linköping, Sweden
25/10/1999 Regulation of cytokine responses, Department of Dermatology, University of Uppsala
Participation in pedagogical conferences:
25 –28 May, 1991 International meeting on lymphoid cells and molecules in infection and immunity, Elsinore, Denmark
9-12 June, 1991 The 11th European Immunology meeting in Finland
15-16 June, 1992 First "Acrival meeting" on chemotherapy
of trypanosomiasis, Marseilles, France
3-4 June 1993 Commission of the European Community, COST Co-operation, Second Acrival COST meeting on Treatment of African Trypanosomiasis, University of Budapest Hungary
15-16 September 1993 27th Trypanosomiasis Seminar - London School of Hygiene and Tropical Medicine
17 September 1993 The Symposium of the British Society for Parasitology
on the Protozoan Surface Molecules, City University, London, UK.
22 October 1994 4th International Congress of Neuroimmunology, RAI, Amsterdam, Holland
25-28 May 1995 XXVIth Annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.
23-29 July 1995 9th International Congress of Immunology
San Francisco, USA
2-6 September 1995 BSP meeting on trypanosomiasis and leishmaniasis
Glasgow, UK
19 January 1996 Trypanosome Workshop, Biomedical Center, Uppsala, Sweden
24-27 May 1996 XXVIIth Annual meeting, Scandinavian Society for
Immunology, Turku, Finland.
28-30 November 1996 Swedish Medical Association Annual meeting, Stockholm, Sweden
4-6 January 1997 The 6th Scientific Conference, The Sudanese
Association of Pathologists, Khartoum, Sudan
9-13 March 1997 The 3rd Conference of the Federation of African Societies for Immunology, Cape Town, South Africa
23-25 May 1997 8th International Center for Biotechnology Symposium
on Cytoplasmic Protein. Tyrosine Kinases- Novum Research Park, Stockholm
15-17 July 1997 The 30th Conference of the Arab Doctors, Sana’a Yemen.
14-16 September 1997 The 5th CFN Symposium on effects of toxicants on gene expression and intracellular signaling- Stockholm.
15-17 April 1998 The 5th International Congress of human antibodies and
hybridomas, 15-17 April 1998, Washington DC, USA.
25-2 July 1998 The International Summer School, Gothenburg, Sweden.
23-27 August 1998 The 5th International Congress of Neuroimmunology, Montreal, Canada
9-12 September 1998 The 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Stockholm, Sweden
7-11 November 1998 The 31 Pan Arab Congress, Khartoum, Sudan
7-8 December 1998 The 1998 Scientific Symposium of the New York Academy of Medicine, New York, USA
14-17 December 1998 The ITM colloquium Congress, Antwerp, Belgium
27 June-1 July 1999 The 10th International Congress on Mucosal Immunity, Amsterdam, Holland
28 August-2 September 1999 1999 meeting on HIV/AIDS and cancer Biology. Baltimore, Maryland. USA.
7 August -9 September 1999 The first International Congress on cytokines and chemokines in Infectious Diseases. Bethesda, MD, USA.
16-19 January -2000 The Pediatrics 2000 International Congress. Saudi German Hospital, Jeddah, Saudi Arabia
9 -13 April 2000 The 9th International Conference of Infectious Diseases, , Buenos Aires, Argentina
April 16 - 19, 2000 The 4th annual Woods Hole Immunoparasitology Meeting, - MBL Woods Hole, MA, USA
12 - 16 May 2000 Immunology 2000. The American Association of Immunologist and Clinical Immunology Society joint annual meeting.. Seattle, WA, USA
May 28 - 31, 2000 The 10th European Congress of Clinical Microbiology and Infectious Diseases - Stockholm, Sweden.
August - 31, 2000 The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis- Stockholm, Sweden.
April 21- 26, 2001 The 11th International Conference on phosphorylated protein, Melbourne, Australia
August 26/8/2001 The 11th International Congress of Immunology. Stockholm, Sweden.
April 20-22/2002 Second Al Ain International Immunology Meeting
June 16-21, 2002 11th International Congress of Mucosal Immunology, Orlando, USA
October 16-17, 2002 3rd GCC Neurology Conference, Bahrain
February 20-23, 2003 The International Symposium of the Immune System in Health and Disease. Osaka, Japan
October 06-08, 2003 Saudi German Academy second international meeting, Jeddah, Saudi Arabia
December 09-12, 2004 International Symposium on Genetics, Dubai – United Arab Emirates
March 03-07, 2004 International Congress f Infectious Diseases, Cancun, Mexico
Qualification as a reader:
9 May 1996, Experimental Neurology, Neurology
Qualification as a Professor:
18 June 2002, Immunology, Neurology
2. Undergraduate course administration
High School students: Biochemistry course to pre university high school students (3 month’s course), Khartoum University. The course had 40 participants. 1982.
Medical Students:
1. Course organizer, Department of Medicine, Alshaab Teaching Hospital, 3 courses in Internal Medicine, for medical students, 35-50 students per course. 1985-1988.
2. Course convener 1988-1998 for 4 courses in Cardiology for medical students, Department of Medicine, Khartoum teaching Hospital, 30-40 students per course.
3. Tutorials and case presentations to under graduate Medical students, Al-Shaab Teaching Hospital, Khartoum, 1987-1988.
4. Course convener 1988-1998 for 4 courses in Clinical Neurology for medical students, Department of Neurology, Huddinge University Hospital, 35-45 students per course.
5. Course Teacher in Free Choice courses for Medical students in Immune System Function in Trauma, Department of Anesthesia and Intensive Care Clinic Ward, Huddinge University Hospital. 1999-2000.
6. Teacher, regular lectures in Clinical Neurology, Immunology and Microbiology for Medical Students, Karolinska Institute - Division of Neurology and Infectious Diseases, Huddinge University Hospital. 1989 -2000.
7. Tutor for year 4 group 4, Unit VII, Central Nervous System, AGU, Bahrain
8. Tutor for year 3 group 5, Unit V Hematology and Immune System, AGU, Bahrain
9. Clinical Professional Skills Program, Unit VII, Central Nervous System, AGU, Bahrain
10. Tutor for laboratory skills in Microbiology, AGU, Bahrain
11. Tutor for year 3 group 7, Unit III GIT and Renal System, AGU, Bahrain: 2001
12. Tutor for year 3 group 8, Unit IV Reproductive System and Endocrinology, AGU, 2001
13. Tutor for year 2 group 2, Unit I Concepts and Principles, AGU, Bahrain: 2002
Departmental activities:
The department coordinator for Unit VI (Musculo-Skeletal and Integumentary system)
The department coordinator for Unit VII (Central Nervous System)
The department coordinator for Unit V (Hematopoietic and Immune systems )
With the following duties:
· Coordinate lab arrangements, timing, material, handouts, etc.
· Coordinate poster preparation
· Upgrade the intranet material for the Unit
· Follow up question preparation.
· Correct the questions in the AO (SAQ, PMP) related to the unit exam
· Review the feedback of the students for the lab activities related to the unit.
· Together with the problem coordinator review the feedback of the tutors on the problems and propose improvement to the Dept. Chairman.
· Attend the meeting for the unit and report to the Chairman.
· Review and propose to the Dept. Chairman improvement the booklet related to the unit.
· Attend the review session for the exam.
· Invaginating the exam (if required)
· Participate in the committee for elaboration of integrated questions interacting with the Dept. Chairman
Participation in graduate activities as the regular scientific seminars and journal club arranged at the department of Anatomy.
Undergraduate seminars:
· Cytokines and Chemokines: from basic science to clinical applications. November 2000
· Zoonoses. January 2001
· Septic Shock. 1 April 2001 (postponed)
· Tuberculosis. 15 April 2001
· Infections: Mother to Child, 16 April 2002.
Department of Molecular Medicine:
Ö Chairman of the Department since January 2003 to date
Ö Constructed curriculums for Molecular Medicine, Genetics and Inherited disorders in the undergraduate teaching units
Ö Continuous tutoring year 2-4
Ö Co-chairman of Unit I Homeostasis
Ö Chairman of Unit V Hematology and Immune System
Ö Co-chairman of Unit VII Central Nervous System
Participation in the activities of University Committees:
Committee Duration
1. University academic committee for Biotechnology from Sept. 2001 to date
2. University Laboratory equipment committee from Sept. 2001 to date
3. College Research and Ethics Committee (Chairman) from Sept. 2001 to date
4. Learning Resource Committee from June 2001 to date
5. Department Research Committee from 1/9/2000 to date
6. College committee for lab medicine Master from 1/9/2000 to date
7. College committee for Basic Science Master from 1/1/2002 to date
8. Unit VII Committee from Nov. 2000 to 2002
9. Unit II Committee from Feb. 2000 to 2002
10. B.Sc. exam Subcommittee from Apr. 2000 to 2001
11. Chairperson of Unit V System Committee from Sept. 2001 to date
12. Unit VI Committee from Sept. 2001 to 2001
13. Laboratory Diagnostic supervisory Committee from Nov. 2001 to date
14. Basic Medical Science Course for Residency Training from June 2002 to date
14. Basic Medical Science Course for Residency Training from June 2002 to date
Compilation of teaching material
v Text books:
Moiz Bakhiet. The role of autoantibodies in the action of cytokines - Frontiers in multiple sclerosis III EDS: Martin Dunitz Ltd, London, 1999
1. Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry-Central Nervous System. 1: 201-208.2001.
v Manuals:
1. Basic immunology: handouts distributed in relevant courses and seminars
2. Techniques in immunology: protocols distributed in practical courses
3. Neurological complications to HIV/AIDS and neuroborreliosis: handouts for medical students
4. Manual for professional skills in Clinical Neurology for undergraduates
5. Departmental evaluation form for Resource sessions
v Posters and intranet resources for undergraduate:
1. HIV poster and intranet resource 2001
2. Tuberculosis Poster and intranet resource 2001
3. Meningoencephalitis
v Construction of Educational Problems:
1. HIV/AIDS 2000/2001
2. Meningoencephalitis 2001/2002
3. Colitis 2001/2002
4. Pneumonia 2001/2002
5. Hepatitis 2001/2002
6. Cancer Epidemiology 2004
7. Neoplasm 2004
8. Spinal cord injury 2004
6. Research and developmental work
1. As a member of the organizing committee, instructor and a lecturer, I am actively involved in development of new courses and renewal of undergraduate education in Pathology, Immunology and Infections Biology, started from autumn term of 1999. The renewal of courses is mainly to meet the needs of teaching in the new school in Biomedicine.
2. As a member of Karolinska International Committee for research and training, I am participating in the development of Karolinska School for Global Health.
3. Coordinator responsible for the Master Program in Master in Laboratory Medicine, AGU
4. Coordinate the agreement between AGU and Karolinska Institute in Sweden for collaboration in research and training.
7. Experience as an educator
Undergraduate activities at Karolinska Institute
Lectures in Clinical Neurology to Medical Students
Lectures in Basic Immunology to Medical Students
Lectures in CNS and Immunology to Medical Students
Numbers of hours= 120 hrs
Undergraduate activities at the Arabian Gulf University:
(Two units per year)
Ø Tutor for unit I, Concepts and principles (72h/year)
Ø Tutor for Unit III, GIT and Renal System (72h/year)
Ø Tutor for Unit IV, Endocrinology and reproductive system (72h/year)
Ø Tutor for Unit V, Hematology Immune System (72h/year)
Ø Tutor for Unit VII, Central Nervous System (72h/year)
Ø Clinical Professional Skills Program, Unit VII, Central Nervous System (36h/year)
Ø Tutor for laboratory skills in Microbiology (56h/year)
Ø Resource sessions in Immunology and Microbiology:
- Tuberculosis
- HIV
- Immunocompromised host
- Septic shock: the role of TNF-a and activated protein C
- Cell cycle and controlling factors
Postgraduate teaching
- 8 students completed their PhD under my full supervision
- 4 students completed their Licentiate (M Phil) under my full supervision
- 4 students completed their Master degree under my full supervision
(For full details see later under scientific portfolio)
Courses for Graduate students:
1. Seminars and Courses in basic Immunology for postgraduates (Department of Neurology Huddinge University Hospital, Karolinska Institute), 1992 -1998
2. Laboratory techniques and Computer applications (see below), 1992-1998 for postgraduates (Department of Neurology, Huddinge University Hospital, Karolinska Institute), 1992-1994.
3. Molecular Biology Techniques in Research and Diagnosis of Infectious Diseases. Applied Course. Unit of Genetics and Molecular Parasitology, National health Laboratory, Institute of Endemic Diseases, University of Khartoum. 7-15/1/1996.
4. WHO/IUIS Refresher Course on Immunology, Vaccinology. Biotechnology and Biosafety Applied to Infectious Diseases, Arusha and Dar Es-Salaam. Tanzania. 4-19 December 1996
5. Organized and participate in the following course for Ph.D. students at Karolinska Institute: Animal models to study immunopathogenesis and treatment of neuroinflammatory disorders 8-29 September 1997.
6. Organized and participated in the EAE teaching course during the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden
7. IMPI seminars, Regulation of cytokine responses in infections and autoimmune diseases. Huddinge, Sweden 21 January 1999.
8. Medical Inflammation seminars, Linköping, Sweden. 8 February 1999.
9. Course in Infectious Diseases for Master students, AGU, January 2001 – June 2001.
10.Course in Basic Immunology Master Students, AGU, March 2002 – June 2002.
11.Course in Molecular Diagnostics, AGU, April 19 – 25, 2003.
Postgraduate activities at the Arabian Gulf University:
Ø Organized Host-parasite interactions Module, Graduate (M.Sc.) Programme In Laboratory Medicine –Core Courses Semester I
Ø Semester II coordinator, MSc in Microbiology
Ø Teaching the Molecular Immunology and Intracellular Signalling Pathways for Master students, the College of Postgraduate, AGU
Ø Principal co-investigator in the department project on pathogenetic mechanisms in children diarrhoea.
Ø Course in Infectious Diseases for Master students, AGU, January 2001 – June 2001.
Ø Course in Basic Immunology Master Students, AGU, March 2002 – June 2002.
Ø Resource sessions for under and post graduate in Cell cycle and Stem cell research (2001-2002).
Ø Regular teaching in medical resident program at the BDF hospital
Ø Supervise 3 Master students at AGU (For PhD and other senior students in Sweden see below at the scientific portfolio)
8. Quality
a. As an organizer and participant in WHO refresher course on Immunology, Vaccinology, and Biotechnology applied to infectious Diseases, I received a letter of award from WHO, Laboratory Training and Support, Division of Emerging and other Communicable Diseases, surveillance and Control.
b. The analysis of evaluation questionnaires, which all participants usually complete at the end of each course, used to clearly show that the training activities are to be considered very successful.
c. In summary, I feel that beside my clinical, administrative and scientific duties, I have to a great extent contributed to the education of undergraduate and postgraduate students. I also gained a lot of experience, which should help the development of teaching in the future.
LEADERSHIP, DEVELOPMENT AND WORKPLACE RELATIONS PORTFOLIO
1. Formal qualifications
a. Administration management course, Strategic Research Center, Sudan 1-4 May 1985
b. Course for teaching at tertiary level - Karolinska Institute, 2 – 6 October 1995
2. Strategic competence, dissemination of information
a. Involved in strategic planning, entrepreneurial ability and dissemination of information for Al-Shaab Teaching Hospital as a Head of the Developmental Committee (1987- 198
b. Active member of the Organizing Committee for the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden.
3. Positions of leadership
Ø Head of Immunology Unit 2002
Ø Chairman of Research and Ethics Committee2002
Ø Chairman of Unit V (Hematopoietic and Immune Systems Committee) 2002
Ø Chairman of Department of Molecular Medicine, Jan 2003
1981-1982 Secretary, Medical Student Association
1982-1983 President of the Association for Cultural activities
1980-1984 President of the Scandinavian Friendship Association
1985-1988 TV Collaborator and presented a series of T. V. programs
1987-1988 President of the High Committee of Development of Al- Shaab Teaching Hospital – Khartoum
1988 Vice president of the Swedish friendship association
Membership of societies and organizations:
A. National Societies and Organizations
1. 1996 Member of the Swedish Association for Immunology Society
2. 1997 Member of the Swedish Medical Society
3. 1998 Member of the Karolinska International Research and Training (KIRT)
4. 1998 Member of the Arabic Swedish Cultural Society
5. 1998 Vice President of the Swedish Sudanese friendship Association
B. Regional Societies and Organizations
1. 1996 Member of the Scandinavian Association of Immunology
2. 1997 Member of the African Association of Immunology
3. 1998 Member of the European Society for the treatment of Multiple Sclerosis
4. 2000 Member of the European society of clinical microbiology
5. 2000 Member of the American Association of Immunologists
C. International Societies and Organizations
1. 1997 Member of the American Academy of the Advancement of Sciences
2. 1998 Member of the International Association of Neuroimmunology
3. 1999 Member of the International society for mucosal immunology
4. 2000 Member of the International society of infectious diseases
5. 2000 Member of the New York Academy of Science
4. Supervisor, lecturer, mentor
· ”Guide”-mentor for 8 Ph.D. students as a main supervisor and for 2 as co-supervisor
· Supervisor of 3 major doctoral research on basic and clinical projects
· Support for colleagues who have been awarded positions of trust and promoted to seniority
5. Competence as a staff manager
I worked as Head Department at several places as my current job also indicates. In addition I served as Head of Research and lab Chief for the Division of Neurology for 3 years. Also, as a Head of Research and Laboratory Chief for the Division of Infectious Diseases for 2 years and for several occasions as Medical director and Acting Head department. These positions have given me great abilities in making decisions, delegation of authorities, ability to apply Group Logic and to bring about general agreement on mutual values in essential questions and to achieve willingness to work together, and also, visionary and organizational abilities.
*Established and currently work as a General Director of HH Aljawhara Center for Molecular Medicine, Genetics and Inherited Disorders
6. Competence in workplace relations
Merits that reflect proficiency in social leadership:
· Social empathy - the ability to give positive feedback and constructive criticism
· Accessibility;
· Openness;
· Ability to make others enthusiastic ;
· Respect for fellow workers;
· Ability to treat fellow workers justly;
· Ability to mediate in disputes
*Establishment of the Center for Molecular Medicine
Introduction:
Molecular Medicine is a highly specialized part of Medicine. It explains the fundamental principles vital to an understanding of:
1. Molecules that are key to the normal functioning of the body and those related to the fundamental mechanisms of the diseases
2. Manipulation of these molecules to improve the diagnosis, treatment, and prevention of disease
3. Human genome
4. Gene regulation and expression in health and disease
5. Genetic engineering
Principles are then applied to the diagnosis and treatment of human disease in Gene regulated disorders, Inherited genetic diseases, Inborn errors of metabolism, Infectious diseases, The immune system and blood cells, Cancer and Public health
Goals
1. To provide genetic testing that is necessary for the diagnosis, management, and counseling of patients and families with inherited diseases
2. To provide molecular diagnostic service
3. To be the reference lab in the Gulf region for genetic disorders
4. To serve as an advanced institution for scientific research and education in the field of molecular medicine
In this context with the above directions and goals, Her Highness Princess Al-Jawhara AlEbrahim, The Wife of His Highness the Custodian of the Two Holly Mosques generously donated 6.2 Million US Dollars to establish the Centre for Molecular Medicine, Genetics & Inherited Diseases. The general layout represents available resources and a complete new building with all facilities and equipment to be connected with the current temporary location.
The center includes expertise in- and facilities for cytogenetics, metabolic disorders and molecular genetics that provide services as for example for:
1. Prenatal Screening: both
2. Before pregnancy: for thalassemias, sickle cell diseases, and chromosomal translocations
3. Prenatal stage: for G6PD (including full genotyping) and counseling, and chromosomal abnormalities (including trisomies).
4. Neonatal stage: for metabolic diseases as phenylketonurias, hypothyroidism, biotin deficiencies and hemoglobinopathies.
5. Diagnosis of Cancers:
Ö Chromosomal translocations: for AML and ALL (by quantitative PCR).
Ö Minimal residual disease; by real-time PCR for IgH TcR rearrangement.
Ö X-linked Genetic disorders: including fragile X-syndrome.
Ö Inherited cancers: such as colorectal and breast cancers.
Hemoglobinopathies:
Sickle Cell Disease.
Hemochromatosis.
Thalassemias.
Directions of our research
The basic research projects at our Molecular Medicine Center address mechanisms in biological systems, computational biology, structural biology and approaches to diagnostics, prophylaxis and therapy.
Research activities are often collaborative between several investigators within the center and from other groups. Joint projects and research grant applications within the institute and with foreign institutions are strongly encouraged. It is recommended that research to be generally organized into units, which include Epidemiology and Biostatistics, Neuroscience (including autism research), and molecular genetics.
The general guidelines for the future plans contain rich ideas with imagination and philosophy, application of high technology, towering quality science, generation of external funds and establishment of national, regional and international networks.
GENERAL:
NOMINATIONS FOR PRIZES:
1. King Faisal International Prize for Medicine, in the field of Molecular Immunology.
2. Kuwait prize in the category of distinguished scientific research of an Arab citizen in the fields of Basic (A) and applied (B) Sciences.
3. Anders Jahres price in Medicine for young medical researcher in the Nordic Countries.
4. Eric K Fernströms price for a young specially promising researcher.
PUBLISHED THE FOLLOWING BOOKS:
As a scientist:
1. Immunopathogenesis of African trypanosomiasis, Interaction between Trypanosoma brucei brucei, T cells and interferon gamma. Doctoral thesis, Karolinska Institute, Stockholm, Sweden, ISBN 91-628-0832-X, 1993
2. Bakhiet M. The role of autoantibodies in the action of cytokines. Frontiers in multiple sclerosis III. EDS: Martin Dunitz Ltd, London, in press. 1999.
3. Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry-Central Nervous System. 1: 201-208.2001.
As a poet:
1. The Mirage and the Rendezvous, published by Khartoum University Press. First edition, 1979. Second edition 1990
2. The Third Dimension, published by Khartoum University Press. First edition 1984. Second edition 1992
3. Foliage for Love and Politics, published by Khartoum University Press. First edition 1993.
4. Entrances for exodus, published by International Press, Muscat - Oman. First edition 1998.
5. The first poetry collection by Moiz Bakhiet, published by International Press, Muscat - Oman. First edition 1998.
6. The see is my entrance to you
7. The sun rises twice 2003
8. Harbors of thirst 2003
9. Cologne and shadows 2003
10.The Second poetry collection by Moiz Bakhiet 2003, Manama, Bahrain
Participated in more than 100 National, Regional and International poem festivals and recitations and won several prices
iNVITED AS A DISTINGUISHED GUEST SPEAKER in more than 10 international meetings in 2000-2004
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خال فاطمة
عادل فضل المولى
Elsuhaili Magzoub
ود شاموق
علاء الدين يوسف علي محمد
Dr. Moiz Bakhiet
فيس بوك
تويتر
انستقرام
يوتيوب
بنتيريست