كوبا تقود العالم من تحت الحصار في البيوتكنولوجي والإنقاذ تتمرغ في وحل الفشل والفساد

Quote: Will Cuba Be The World's Next Leading Biotech Hub؟ By Rob Wright, Chief Editor, Life Science Leader Life Science Leader magazine was recently invited to attend The Economist’s War On Cancer healthcare forum in Boston, Sept. 28, 2016. Though all of the day’s sessions were intriguing, the one that got me up out of my chair to track down a speaker before his exit occurred at 4 p.m. Entitled, “Going Global – Examples Of Cancer Advances From Around The World,” the first person to speak was Kelvin Lee, M.D., immunology chairman from the Roswell Park Cancer Institute. Dr. Lee says that his experience in working with Cuba began quite by accident in 2011. Despite Popular U.S. Belief, Cuba Biopharma Is Not Stuck In The 1950s “At the time, we at Roswell Park in Buffalo thought that Cuba was stuck in ‘I Love Lucy’ days,” admits Dr. Lee. “We believed that there was no possible way that there could be any biotechs in Cuba.” An investigator from Cuba’s Center of Molecular Immunology (CIM) happened to be visiting family in Pittsburgh. “She called us and said, ‘Hey, I’ve heard about your cancer reputation. Can I come up and tell you about our cancer vaccine؟’” recalls Dr. Lee. “So she came up to Roswell and gave this remarkable talk about some really innovative lung cancer vaccines (i.e., CIMAvax) and some other cancer vaccines they have worked on. We were surprised that all of this was happening in Cuba.” In 2012, a team from Roswell Park went to Cuba to develop a more significant relationship, which led to an effort to bring the country’s cancer vaccines into the U.S. for clinical trials. Dr. Lee surmises the biopharmaceutical innovation taking place in Cuba is the result of two factors: The country has made public health a national priority. The nation, as a result of the U.S. embargo against it, is extremely economically constrained. “The life expectancy in Cuba is the same as that of the United States and Canada, as is infant mortality rates,” Lee attests. “But they spend one-fifth per capita what we spend on healthcare.” According to Lee, how Cuba has been able to compete with U.S.-type healthcare statistics is by taking innovative products and applying them to populations at a primary healthcare level. “This is a very unprecision/unpersonalized medicine approach,” Lee attests. “Cuba derives innovation from a unique set of biotech industries that function as a closed loop. So when they do their RandD, the RandD people walk their product across the hall to their preclinical development people, who then take it to their manufacturing people, etc.” The CIM runs its own Phase 1 through Phase 4 studies, and once the drug is approved by the various regulatory agencies, the CIM then produces the drug for commercial consumption, both in Cuba as well as other parts around the world. Because of this closed loop, there is no “Valley of Death” when it comes to Cuban drug development. “They are very careful, and have world-class facilities,” Lee asserts. “In Cuba, there are about 8 to 10 biopharmaceutical companies the size and caliber of Celgene/Millennium.” I suddenly feel like I have been living under a rock for not knowing this about Cuba. So I ask others seated at my table if they were aware of this, and get a unanimous “No.” After Lee’s presentation, I introduce myself and tell him that I am stunned to have not known that this was going on in Cuba. He replies, “No one does,” and proceeds to tell me the story of Cuba and interferon. Cuba’s Isolation Leads To Cuba’s Innovation In 1980, when the world saw the promise of interferon as a potential cure for cancer, so too did Cuba’s Fidel Castro. As a result, the dictator sent six scientists abroad to learn how to produce the drug. Upon their return, a small facility in western Havana was outfitted as a laboratory, and in just 42 days, they produced natural interferon-α, and thus the Cuban biotechnology industry was born. Because of the U.S. embargo, Cuba has had to become fairly self-reliant, which it has, producing 70 percent of the medication it needs, including vaccines for 21 different diseases. According to the WHO, the Cuban biotechnology industry holds around 1,200 international patents and markets pharmaceutical products and vaccines in more than 50 countries. Cuba boasts having more than 300 biotechnology centers. The western Havana biocluster alone employs 12,000 workers and more than 7,000 scientists and engineers. Countrywide, it is estimated that Cuba has about 1.8 scientists per 1,000 inhabitants, a level comparable to that of the EU (though with a much smaller GDP). Some might think it hard to imagine Cuba ever competing with the likes of Boston or San Francisco as a world-leading biotech hub. But perhaps this is not as far-fetched as you might first think. For starters, the country is about the size of Pennsylvania, and has a population #####alent to the state of Ohio. But even more important is the country’s biopharmaceutical results. For as Dr. Lee and his colleagues can attest, Cuba’s cancer initiatives were sufficiently eye opening to prompt Roswell Park to secure a license from the U.S. Office of Foreign Assets Control (OFAC) to partner with CIM toward the development of the country’s therapeutic lung cancer vaccine (i.e.,, CIMAvax). It’s enough to make you wonder what else Cuba might have in its pipeline worth learning more about, and ask, “Who is this 54-year-old U.S. embargo really hurting؟” For lung cancer, the biggest cancer killer (by far) in the U.S., remains an unmet medical need, and Cuba’s CIMAvax could provide more than mere hope.

Quote: How a Communist island nation became a biotech powerhouse March 31, 2016 · 6:00 PM EDT By Rachel Gotbaum For years, Cuba’s Fidel Castro invested in the creation of the country's own medical industrial complex. Now Cuba is considered to be a major developer of vaccines and other important medical treatments. Jose DiFabio, who was Cuba’s representative for the Pan American Health Organization, says the isolated Communist country invested in medical research out of neccessity. “Cuba considered medical science as a responsibility it had to move into and that’s why it created a very large medical and scientific workforce,” says DiFabio. A major driver was the US embargo, which limited Cuba’s ability to import medicine, he says. “The priority was to have the medicines required and also the vaccines required and the biotechnology products required for the population." One effort yielded Cuba's own hepatitis B vaccine in the 1980s. “Almost all of the country’s population has been vaccinated," he says. "Probably Cuba will be the first country to eliminate hepatitis B.” Currently Cuba has long been developing a vaccine for lung cancer, CimaVax, which many US researchers are interested in testing. “It a vaccine directed against a protein that is involved with growth of cells,” says DiFabio. He added that more research is being done on this vaccine to treat other cancers. “Those cancers that are somehow related could be treated with CimaVax,” he says. Some of the medical developments promise immediate help, DiFabio says. An example: a cream used for diabetic foot ulcers. It has already been used on 150,000 patients worldwide. “Amputations are avoided,” he says.

Quote: “Almost all of the country’s population has been vaccinated," he says . "Probably Cuba will be the first country to eliminate hepatitis B.

Quote: رفع الحصار يعنينا فقط عند ذهاب الانقاذ من المشهد السياسى وتطهير كل من الفضاء الاقتصادى والاجتماعى من نفوذهم ووجودهم الذى لم يجلب على المواطن الا الفقر وتفريق الكلمه والتمييز بكل اشكاله

Quote: (-) والحكومة نتاج شعب اي تاتي من الشعب فامريكا تخاف من الالتزام للشخص السوداني اكثر من غيره

Quote: biomedical researchers have managed to excel at creating low-cost vaccines, developing cancer treatments and screening infants for disorders.

Quote: Unlike many of its Latin American peers, Cuba has had a stable government for decades, which has allowed the country to carry out long-term plans. And the country’s isolation from foreign aid spurred innovation in ways that few other low-income nations can claim. An often-heard verb is resolver — to fix problems, often on your own. “Most Cuban scientists now didn't know Cuba before the blockade, and the fact you cannot get any device is so familiar,” says Luis Montero Cabrera, a computational chemist at the University of Havana. There is something of a perverse pride: people who have spent their lives overcoming obstacles, he says, make the best scientists.

Quote: Cuba is an enthusiastic user of medical testing, especially for newborns. In 2015, the World Health Organization declared Cuba the first country in the world to eliminate mother-to-child transmission of HIV — an achievement reached through the use of intensive screening and drugs for HIV-positive mothers

Quote: [The increase of the Cuban biotechnological products portfolio and of exports transformed biotechnology into one of the strategic sectors of the economy. This factor – among others – motivated the creation, in December 2012, of the BioCubaFarma Business group, which integrated the work of 38 institutions of the Scientific Hub West of Havana and of the former QUIMEFA Business Group. According to its deputy director, Doctor Eduardo Martínez Díaz, BioCubaFarma is coordinating today the work of 31 enterprises and 62 productive installations. The group has a human capital of 22,000 workers; its installations currently produce 569 generic medicines out of the 857 in the basic table of the country’s medicines. The enterprise is working with more than 450 products corresponding to RandD programs, has 900 sanitary registries in more than 50 countries and has been given more than 1,800 patents abroad.

Quote: ولاية الخرطوم بها حوالي 0.9 مستشفي لكل 100000 ألف مواطن و125 سرير لكل 100000 ألف مواطن ،

Quote: كوبا تستحق الإشادة بلا شك فهى قد نبغت في عدة جوانب و ليس البيوتكنولوجى فقط بل في الجانب الرياضى أيضاً و لها الكثير من الأبطال المشهورين في عدة مجالات رياضية