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 Re: Treatment of Neurofibromatosis Type 2 (Re: Ammir Mohamed)
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:Medication
No effective medical therapies are known for neurofibromatosis type 2 (NF2). However, in rare instances in which surgical resection of symptomatic ependymomas is not possible, chemotherapy with lomustine, vincristine, and prednisone, or carboplatin and vincristine, following radiation therapy, may serve a palliative function.
As previously mentioned, therapeutic use of erlotinib has shown promise in the treatment of unresectable, progressive vestibular schwannomas, resulting not only in a decrease in tumor size but also in improvement in auditory function. Further clinical trials are in order before use of this oral chemotherapeutic agent can be recommended on a routine basis.[9] A trial of bevacizumab, an antivascular endothelial growth factor monoclonal antibody, also showed some efficacy in the shrinkage of vestibular schwannomas; the drug improved hearing in some patients with unresectable tumors.[10]
Early in vitro studies have suggested that Gleevec, a tyrosine kinase inhibitor, may be useful in the treatment of vestibular and spinal cord schwannomas in patients with NF2.[11]
ربنا يشفى عباده
مع التحية
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ابن النخيل
Elawad
سيف النصر محي الدين
عمار عبدالله عبدالرحمن
فيس بوك
تويتر
انستقرام
يوتيوب
بنتيريست